I'd love to make an animated series in the Muppets universe. I'd call it Henson High School. Every episode, the characters would learn valuable life lessons, there would be a nice amount of Sesame Street positivity and classic Muppets humor.
Not everyone grows up on Sesame Street. Think 90's sitcom set in a Muppet High School. I imagine it would deal with timeless issues about teenage life but also explore some more modern situations, all with a classic Muppet Show feel. I think it would be fun :)